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However, GLP-1 can act as a helpful addition especially for patients who: Have obesity or are overweight Have type 2 diabetes or metabolic syndrome Need improvements in multiple metabolic risk factors (not just cholesterol) Who Benefits Most The cholesterol and lipid benefits of GLP-1 tend to be greater in: People who lose significant weight on it Those with elevated triglycerides to start Patients with insulin resistance or type 2 diabetes Individuals implementing lifestyle changes (diet, physical activity, etc.) alongside medication What to Expect & Important Things to Know Timeframe : Changes in lipid levels usually show up over months not immediately

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While they produce modest LDL cholesterol reductions of 2-10%, statins remain first-line therapy for patients requiring significant lipid lowering, and GLP-1 agents work best as complementary therapy alongside statins

Zhang, Q., et al

And boom, significant improvements, ability to go off of the hardcore medications that were expensive that, you know, she was having to get from Canada cause they were too expensive in the United States