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In addition to the rapid epigenetic modulation of glutamatergic function, preclinical studies showed that boosting mitochondrial metabolism of LAC protects against oxidative stress, rapidly ameliorates insulin resistance, and reduces neuroinflammation by decreasing proinflammatory pathways such as NFkB in hippocampal and cortical neurons

Glucagon-Like Peptide-1 (GLP-1) receptor agonists, including semaglutide, have shown immense promise in reducing body weight, improving blood glucose control, and providing cardiometabolic benefits

A 2026 systematic review and meta-analysis of direct comparisons reached a similar conclusion while being honest about its limits