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Lash LH, Putt DA, Matherly LH

Adapted from Ruiz-Colon et al, 2014), Recommended Treatment: No known antidote, or FDA-approved medications to manage xylazine overdose or withdrawal Xylazine is not detected in routine toxicology screens (Rubin, 2022) naloxone treatment does not appear to be of benefit (Ruiz-Colon et al, 2014) Maintain respiratory function & blood pressure & supportive care (Ruiz-Colon et al, 2014

Growth hormone deficiency in 'little' mice results in aberrant body composition, reduced insulin-like growth factor-I and insulin-like growth factor-binding protein-3 (IGFBP-3), but does not affect IGFBP-2, -1 or -4

Treatments include dietary interventions to enhance iron intake from iron-rich foods and oral iron supplementation, despite potential gastrointestinal side effects ( 2.2 Iron overload in the brain In contrast to iron deficiency, excess iron in the brain is neurotoxic due to its ability to produce reactive oxygen species (ROS) and resultant oxidative stress (Salvador et al., 2010)

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