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Despite this promise, several critical limitations remain: No large-scale, randomized controlled human trials to confirm efficacy, safety, or long-term impact Toxicology and pharmacokinetic data are lacking, especially for chronic use or high-dose regimens Only one stereoisomer (all-L form) has been tested

It should be noticed that in 2000 the first leading cause of YLDs was unipolar depressive disorders

Though human data remains sparse

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B., et al., ERK Activation Induced by Selenium Treatment Significantly Downregulates /Secretase Activity and Tau Phosphorylation in the Transgenic Rat Overexpressing Human Selenoprotein M, International Journal of Molecular Medicine 24 (2009): 9196