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This could be due to a variety of reasons such as genetic factors, underlying health conditions like pernicious anaemia, or gastrointestinal surgery

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Cellular Dysfunction: Depletion of glutathione can adversely affect cellular health, potentially leading to impaired cellular function and increased susceptibility to damage

De Heer J, Rasmussen C, Coy DH, Holst JJ: Glucagon-like peptide-1, but not glucose-dependent insulinotropic peptide, inhibits glucagon secretion via somatostatin (receptor subtype 2) in the perfused rat pancreas

Indeed, both in vitro and animal studies indicate the antioxidative action of amlodipine 88