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Future studies needed To fill existing research gaps, we recommend future studies to examine not only the quantitative change in calorie intake but the qualitative changes in macro- and micronutrient intake including dietary patterns for patients using highly effective anti-obesity medications

A study in C57BL/6J mice using a dose comparable to a 5000 g tablet (30.46 g/day) for humans found a depletion in Bacteroides but no change in cecal short-chain fatty acids (SCFAs) or markers of dextran sulfate sodium (DSS)-induced colitis with B12 treatment, including colon length and fluorescein isothiocyanate-dextran permeability test [15]

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If youre considering supplementation, look for L-carnitine tartrate or acetyl-L-carnitine, as these are the most bioavailable forms, and consult a dietitian or healthcare provider to ensure it aligns with your performance goals

The Satiety Switch: Viscous Fibre (PHGG) One of the most effective ways to naturally support GLP-1 is through soluble fibre that thickens slightly and ferments slowly in the gut