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Significant weight reduction can lead to changes in facial volume, skin laxity, and the distribution of subcutaneous fat

Important safety considerations include a boxed warning for thyroid C-cell tumors (contraindicated in patients with personal/family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2), and pregnancy avoidance (with a 2-month washout period before conception)

Mood and cognitive effects GIP and GLP-1 receptors exist in the brain

[55] Senescent cells secrete a harmful mix of inflammatory molecules known as the senescence-associated secretory phenotype (SASP)