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Diabetes Res Clin Pract 97(2):258266 Horowitz M, Rayner CK, Jones KL (2013) Mechanisms and clinical efficacy of lixisenatide for the management of type 2 diabetes

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Sarcoplasmic/endoplasmic reticulum Ca2 + -ATPase 2a (SERCA2a), a pivotal protein in the excitationcontraction coupling process, maintains calcium homeostasis in cardiomyocytes by transporting Ca2+ from the cytoplasm back into the sarcoplasmic reticulum

Aging reduces both GAG synthesis and retention capacity

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