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Peer review Peer review information Nature Metabolism thanks Darleen Sandoval and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

Regular moderate exercise supports metabolic health but excessive or intense training should be avoided, as this can compound hypothalamic suppression

"Our new GLP-1 Weight Loss Support Training course empowers fitness and health coach professionals to stay within scope while becoming trusted allies in client transformation." While other programs may focus primarily on the clinical or pharmacological side of GLP-1 medications, ISSAs course takes a whole-person approach, combining insights from exercise science, health coaching, and emotional wellness to guide sustainable change

Hospital Stay: Many patients are able to go home the same day of surgery or after a short hospital stay (typically 24-48 hours), depending on their individual condition and recovery progress

GLP-1based agents such as semaglutide and tirzepatide are now widely studied in laboratory models of obesity and chronic disease