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Of importance, GLS inhibition and IDH1 mutations are synthetically lethal under oxidative stress, and GLS inhibition with CB-839 has been shown to selectively radiosensitize the IDH1 mutated xenograft GBM tumors [159]
Non-reciprocal regulation of the redox state of the glutathione-glutaredoxin and thioredoxin systems
Food Chem Toxicol 121:450457 Castillo-Gonzalez DA, Dorsey-Trevino EG, Gonzalez-Gonzalez JG, Garcia-Leal M, Bautista-Orduo KG, Raygoza K, Gionfriddo MR, Ospina NMS, Rodriguez-Gutierrez R (2020) A deeper analysis in thyroid research: a meta-epidemiological study of the American Thyroid Association clinical guidelines
It is also important to note that if an agencys budget exceeds $100 million, they must allocate the maximum amount, 3.2%, to the SBIR program, meaning that some agencies like the DoD and the HHS (NIH) have much larger budgets (and award larger number of companies with higher $) than some of the other agencies with smaller budgets
