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Efficacy of once-weekly tirzepatide versus once-daily insulin degludec on glycaemic control measured by continuous glucose monitoring in adults with type 2 diabetes (SURPASS-3 CGM): a substudy of the randomised, open-label, parallel-group, phase 3 SURPASS-3 trial

A subsequent trial using a complete meal (rather than sugar alone) confirmed 30-33% reductions in blood glucose and 31-38% reductions in insulin across three dose levels

Cell-free hemoglobin limits nitric oxide bioavailability in sickle-cell disease

Even if you have a healthy A1c, you can be insulin resistant, which is why this is important to measure alongside other measures

But the 28-day stability window means only four of those six weeks fall within the safe use period