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Mendoza-Milla C, Rodrguez CM, Alarcn EC, et al

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Neuro-ophthalmology encompasses the spectrum of neurologic, ophthalmic, and systemic disorders affecting the optic nerve, central visual pathways, or neural control of eye movements

These reports and our data indicate that, in addition to an extra copy of APP , the brains of individuals with DS are exposed to an unfavorable environment where A production is enhanced due to increased oxidative stress