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Inflamm Bowel Dis 22:20782097

Injuries to the lumbar region can result in some loss of function in the hips, legs, and bladder control

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Several factors combine: absence of active patent (thus little pharmaceutical incentive to finance trials), ambiguous regulatory status in most countries, high cost of a phase I to III clinical trial (several million to tens of million euros), difficulty in defining a precise indication acceptable to a regulatory authority