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For the right patient, under proper medical care, it can be truly life-changing

Actionable next steps for researchers: Define the primary metabolic endpoint before compound selection weight/adiposity studies favour tirzepatide

Retatrutide research has revealed a similar GI profile, but with a few additional considerations related to its glucagon component

NICE also says tirzepatide can be prescribed in primary care or specialist services if people meet the criteria and NHS Englands commissioning guidance

Patients should not discontinue semaglutide without consulting their healthcare provider, as abrupt cessation may lead to deterioration in glycemic control or weight regain