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Both classes of enzymes are vulnerable to inactivation by electrophiles such as dehydro-alanine (acrylate) glutathione when they are in their reduced form

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Moreover, inhibition of PFKFB3 by 3PO has been shown to exert anti-inflammatory and antifibrotic effects on experimental lung fibrosis in mice [12]

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The participants were between the ages of 20-50 years old, did not have any chronic medical conditions, did not have any presence of acute illness, were within the normal BMI category (18.5-24.9 kg/m2), and did not use any drugs or dietary supplements on a frequent and/or mandatory basis