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The STEP 1 trial of once-weekly injectable semaglutide reported substantial average weight loss in adults with obesity, as published in the New England Journal of Medicine

Due to the high cost and significant side effects of these medications, many studies show that more than half of patients have stopped them by the 12th month

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For people on higher dose protocols, the 10mg protocol and the considerations around higher unit doses are relevant, since higher doses tend to produce stronger side effect profiles, particularly in the first 24 to 48 hours post-injection

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