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In addition to its outstanding glucose-lowering effect, DPP-4i have also shown non-metabolic functional activities, including anti-inflammatory effect and cardiovascular protection, particularly with regards to BP regulation
For example, in the SELECT trial (17,600 patients with cardiovascular disease and obesity but without T2D), weekly subcutaneous Semaglutide (2.4 mg) reduced the risk of major adverse cardiovascular events (MACE heart attack, stroke, or cardiovascular death) by 20% compared to placebo (HR 0.80
Emerging research points to a critical underlying mechanism: profound, systemic oxidative stress and the depletion of the body's master antioxidant, glutathione
In addition, health systems may begin incorporating GLP-1 therapies into more preventive care models
Compounded GLP-1 programs, manufacturer savings cards, and cash-pay telehealth clinics have opened up real alternatives
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