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Disruption of NOS1 dimerization can lead to abnormal CDK5 phosphorylation and activation, which impede synaptic plasticity and promote AD development [83, 84]

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The following information was also obtained from each study: first author, year of publication, country of origin, age range, sample size, daily dose, duration of intervention, and principal outcome

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This situation is also accompanied by the altered efficacy of G-protein stimulation in opioid-sensitive CNS structures and a reduction in the expression of several opioid receptor mRNAs, which indicates that NP can recruit and modify several opioidergic circuits in the brain [139]