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Effects of fibrates on cardiovascular outcomes: a systematic review and meta-analysis

Semaglutide primarily targets GLP-1 receptors

GLP-1 GLP-1 T

Additionally, patients may prefer the weekly injection of semaglutide over the daily injections of liraglutide, as indicated by the lower discontinuation rates for weekly vs daily injections of GLP-1 receptor agonists observed in some studies [36,37,38,39]

The durability of metabolic benefits after washout, the consequences of chronic pan-ERR activation in heart and kidney, and the potential for tolerance or compensatory network changes require longer studies