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Complementary animal work with tripeptide-copper complexes used an experimental skin-wound model and, in parallel, cultured fibroblasts

Despite the absence of specific protocols for cirrhosis patients, sleep diaries are heralded as the gold standard for subjective sleep assessment ( Objective methods for sleep disorders assessment in cirrhosis include the polysomnography test which stands as the gold standard for diagnosing sleep disturbances, but its practicality is hindered by high costs and patient compliance challenges

The usual adult dosage is 1 ampoule daily for 5 days or as directed by a physician

Acknowledgements This work was supported by National Natural Science Foundation of China (82170873, 82371424), and Tsinghua University Spring Breeze Fund (20211080005)

An incidence ranging from 1% to 11% has been reported for hepatodiaphragmatic nodules in Fischer 344 rats (Eustis et al