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This proposal was based in part on the finding that [GSH]:[GSSG] in the secretory pathway and in microsomal vesicles is similar to the ratio found in redox buffers that are effective for the oxidative folding of proteins in vitro that is, between 1:1 and 3:1 (Bass et al , 2004

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Figure 2), which can cause oxidative damage to proteins, nucleic acids, amino acids, and lipids, in addition to increased mitochondrial and cellular damage and death

doi: 10.3389/fnmol.2023.1305208 44 WeiMWuTChenN