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By site-directed mutagenesis, it is possible to obtain stable and reproducible mutants with predictable gene expression regulation related to riboflavin biosynthesis (Table 3)

Meanwhile, Luciferase activity assays revealed no significant difference in GGCT promoter activity between Gln+ and Gln- groups, indicating that Gln does not directly regulate GGCT transcription (Fig

Polyphenols are being extensively investigated in cell-based studies, animal models, human studies, and clinical trials as antidiabetic and neuroprotective agents

In 87 patients with NAFLD and T2D, 12-week treatment with liraglutide 1.8 mg/d resulted in similar reductions in intra-hepatic fat as treatment with metformin, whereas liraglutide was significantly more effective than gliclazide