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We implemented the Bayesian Confidence Propagation Neural Network (BCPNN) for sensitivity analysis, with its specific computational formula detailed in Supplementary Table 1
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its absence is informative but not disqualifying, especially when mechanistic and physiological evidence is otherwise robust ( Finally, insurmountable technical barrierssuch as inability to manufacture stable formulations, extreme immunogenicity, or lack of feasible delivery routesmay justify abandonment independent of biological plausibility
The therapy is typically delivered through injections and overseen by healthcare professionals
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