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These symptoms develop gradually because the body stores several years worth of B12 in the liver, meaning deficiency takes time to become clinically apparent

In addition, the reduction of nonnative disulphide bonds would lead to an increase in the level of GSSG, particularly if the resulting cysteine residues remain reduced or reform native disulphide bonds through an Ero1catalysed oxidative pathway

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10.1016/0008-8749(91)90343-A 48

Here, B12 shots are given once a month