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We calculate optimistic and pessimistic scenarios by flexing these key assumptions to plausible higher and lower values

What Realistic Actually Means (And Why It Matters) A lot of weight loss expectations and timelines online arent realistic

In the STEP and SURMOUNT trials for semaglutide and tirzepatide respectively, weight loss curves generally began to flatten between weeks 36 and 60, reflecting the physiological set point adaptation that occurs as appetite suppression becomes partially offset by metabolic adaptation

For hepatic impairment, altered protein binding and slowed metabolism can alter exposure