headache after taking semaglutide Headache: Understanding Causes Of Headaches, Side Effects And Relief Strategies Headache won't go away :

Your body is adjusting to reduced caloric intake and metabolic changes

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However, the extent of appetite suppression can vary from person to person

This early response occurs because semaglutide immediately activates GLP-1 receptors in your hypothalamus, the brain region controlling appetite and satiety signals