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45 :51-88 doi: 10.1146/annurev.pharmtox.45.120403.095857

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Physicians in charge decided plasma sampling to measure plasma VPA concentrations, treatments and L-carnitine dose regimen, which included an intravenous 100 mg/kg loading dose followed by a maintenance dosing up to 3 g/day in 3 divided doses for 3 days (or until ICU discharge)