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These findings, however, are non-specific, and diagnosis must be confirmed using other methods

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Endocrinology 164:115 Leenders F, Groen N, de Graaf N, Engelse MA, Rabelink TJ, de Koning EJP, Carlotti F (2021) Oxidative stress leads to -cell dysfunction through loss of -cell identity

The HPA axis is involved in many psychopathological processes, such as depression, and long-term amphetamine abuse can damage the HPA axis, leading to impaired negative feedback, adrenal enlargement, and hypercortisolemia 39,40