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Strength of recommendation: 2C Recommendation 5.5

Nrf2-Keap1 signaling as a potential target for chemoprevention of inflammation-associated carcinogenesis

doi: 10.1001/jama.2019.2942 [DOI] [PMC free article] [PubMed] [Google Scholar] 17

26 Sirtuins manipulate the metabolism reprogramming via directedly altering the activity of metabolic enzymes by NAD + -dependent modification or changing their expression by regulating transcription factors