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BEST PRACTICES BOX: COMPREHENSIVE METABOLIC AND MITOCHONDRIAL MONITORING Establish baseline measurements of body composition (DEXA or bioimpedance), metabolic rate (indirect calorimetry if available), fasting glucose and insulin (HOMA-IR calculation), glucose tolerance testing, lipid profile, and exercise capacity (VO2max or time-to-exhaustion testing)

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The earlier intervention raised hsCRP more than the latter

Based on these 3 applications, the inter-rater reliability of the guideline showed "good reliability" (ICC = 0.74