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However, rodent studies have shown that long-term Glucagon-like Peptide-1 Receptor Agonists (GLP-1RAs) exposure can induce proliferative changes, including thyroid C-cell tumors and epithelial cell hyperplasia, through GLP-1Rmediated pathways, raising concerns about potential mitogenic effects in other tissues

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The Nature Communications study was funded in part by the National Institutes of Health (grants P30 AI036214, R01DK121619 and UM1TR004528) and the James B

GLP-1RAs may delay gastric emptying and cause gastrointestinal symptoms