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This mitochondrial dysfunction leads to a reduction in sperm motility and viability [29, 30]

Drafting the article: Ghaith, Johnson, Ghanem, Michaelides, Bon Nieves, Marsh, Spinner

Its medicinal-chemistry program, described in detail by Kruse and colleagues, introduced several deliberate substitutions into the amylin backbone: residues borrowed from rat amylin (which does not readily form fibrils) to blunt the aggregation tendency, an engineered salt bridge to stabilize the central helix, and a C 20 fatty-diacid moiety attached through a linker to promote reversible binding to serum albumin

1,5 The intestinal mucosa is lined by tightly packed epithelial cells with intracellular tight junctions that form a barrier to regulate what crosses from the gut into the body