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Out-of-scope-public comments are not addressed in this CY 2026 OPPS/ASC final rule with comment period

AOD-9604 peptide benefits are commonly explored in controlled laboratory studies investigating: Selective fat reduction and lipolysis pathways Inhibition of new fat cell formation (lipogenesis) Metabolic efficiency and energy utilisation Preservation of lean tissue during fat metabolism studies Weight regulation and adipose tissue research These observations relate to experimental laboratory studies and are not medical claims

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The evidence supporting lipotropic injections themselves remains limited and of low quality

The peptide demonstrates regional selectivity in its fat-reducing effects, showing particular efficacy in reducing visceral adipose tissue (deep abdominal fat) and subcutaneous fat deposits