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For once-weekly preparations such as semaglutide (Ozempic, Wegovy) and dulaglutide (Trulicity), the time of day is generally less critical because these long-acting formulations maintain steady drug levels throughout the week

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an early phase 1b study reported that co-administration was feasible and that each components pharmacokinetics were not meaningfully altered by the other, which motivated the phase 3 program [3]

The effect of St Johns wort extracts on CYP3A: a systematic review of prospective clinical trials