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Mammalian toxicology of insecticides 12:184220 Saad EM, Elassy NM, Salah-Eldein AM (2022) Effect of induced sublethal intoxication with neonicotinoid insecticides on Egyptian toads ( Sclerophrys regularis )

12,13 While certain genetic disorders (eg, Kallmann syndrome) are linked to impaired function of the hypothalamus or pituitary gland from birth, toxic exposures and other environmental factors, both in utero and later in life, are also known to interfere with the activities of the gonadotropic hormones

thus, the phenotype is manifest fully in males whereas female heterozygotes display varying degrees of G6PD deficiency, due to alternate X-chromosome inactivation 3,4

Li S.Y., Zhang T.J., Wu Q.X., Olounfeh K