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The ingredient ectoin is an amino acid derivative produced via fermentation from ectoine - a naturally occurring molecule found in a wide range of bacteria that live in extreme conditions

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However, individuals with copper metabolism disorders (Wilsons Disease) should avoid due to abnormal copper regulation

the reduced dye then undergoes non-enzymic oxidation in air, so the addition of a relatively small amount of methylene blue will effectively deplete NADPH, and would be expected to stimulate any pathway that reduces NADP+ to NADPH