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Other risk factors for gallstones include: having been pregnant having a family history of gallstones having recently lost lots of weight taking oral contraceptives being sedentary undergoing high-dose estrogen therapy having a gene variant that significantly increasesthe risk of developing gallstones having a high intake of dietary fat being over 60 years of age having Native American heritage taking cholesterol-lowering drugs called statins having diabetes More women get gallstones than men

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Increased pressure: Increased pressure on the inside of the ankle or knees can lead to nerve compression or entrapment, which can lead to peripheral neuropathy

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Nature 445, 102105