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Following a single oral 100 mg dose to healthy volunteers, mean plasma AUC of sitagliptin was 8.52 M-hr, C max was 950 nM, and apparent terminal half-life (t 1/2 ) was 12.4 hours

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Its entraining effects on circadian processes in brain cells, aligning neural activity and modulating synaptic transmission with the natural day-night cycle, could also potentially mitigate the development of AD