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Although no direct experimental evidence currently exists demonstrating that natural products regulate bone remodeling via modulation of gut hormone secretion, previous studies have shown that GLP-1 receptor agonists can significantly increase bone mass, improve bone microarchitecture, and reduce bone resorption markers such as C-terminal telopeptide of type I collagen (CTX-1) in osteoporotic or diabetic models ( Despite promising preclinical outcomes, clinical translation faces several major challenges