Contact your GP for B12 testing if you have: Symptoms suggesting deficiency (persistent fatigue, pins and needles, memory problems, glossitis) Risk factors for deficiency (vegan diet, gastric surgery, long-term metformin or proton pump inhibitor use) [1] [4] Concerns about whether your current supplementation dose is appropriate Underlying conditions affecting B12 metabolism (kidney disease, liver disease) Unexplained high B12 levels on a blood test when not taking supplements Routine monitoring is essential for patients receiving therapeutic B12 injections
It plays a central role in cellular detoxification, the neutralisation of reactive oxygen species, and the regeneration of other antioxidants including Vitamins C and E
The proposed chain of effects looks like this: NNMT inhibited nicotinamide is no longer inactivated by methylation and becomes available for conversion to NAD+
If you had a real deficiency, the change tends to be more noticeable
Some research indicates that elevated doses of B vitamins improve sensory-motor control
