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These included arrhythmias induced by digitalis overdose [154], hyperkalemia [105], hypokalemia [106], succinylcholine [102], bupivacaine [122], lidocaine [103], neuroleptics [133], major vessel occlusion [66,67,68,69,70,71,72,73,74,75,76], major intoxication (alcohol, lithium) [80,81], permanent bile duct occlusion [78], maintained intra-abdominal hypertension [77], and hypoxic injury and reoxygenation arrhythmias [123]
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But the mechanistic rationale is strong, and early anecdotal reports from researchers and clinics using the combination suggest meaningful improvements in appetite control, energy expenditure, and overall metabolic response compared to retatrutide alone
It's important to remember that retatrutide remains investigational, and ongoing Phase 3 trials will determine whether these promising findings translate into long term clinical benefits