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A BCL-xL/BCL-2 PROTAC effectively clears senescent cells in the liver and reduces MASH-driven hepatocellular carcinoma in mice

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Both groups showed a similar body-weight loss but the pharmacological treated group lost 68% more fat and better maintained lean mass, so this additive effect could be attributed to the pharmacological effect and not to calorie restriction

Andresen TL, Thompson DH, Kaasgaard T