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Symptoms often evolve gradually and fluctuate based on ongoing exposure, stress load, and regulatory capacity

437,438,439 While primarily acting as a tumor suppressor, cellular senescence also plays a critical role in tissue repair, promoting localized fibrosis and immune cell recruitment to clear damaged and senescent cells

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Published safety data shows negative results in repeated-dose toxicity studies, skin irritation protocols, sensitization assays, and genotoxicity testing

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