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A recent study showed an increase in dental fluorosis in children in areas with fluoridated water

Korean J Ophthalmol (2015) 29:2139

Cellular membrane receptors (e.g., G-protein-coupled receptors (GPCRs)), insulin, and growth factors trigger category I PI3Ks

These changes mark a shift from an external injury stimulus to amplified pain processing, which complicates treatment options for patients with chronic pain (2)(18)