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A number of phenotypic elements should be carefully assessed, including neurological and cognitive symptoms (such as impairment of concentration and short-term memory, perceptual and sensory disturbances, sensory and emotional overload phenomena), autonomic manifestations (such as orthostatic intolerance, palpitations, gastro-intestinal symptoms), neuroendocrine manifestations (such as loss of thermostatic stability, intolerances of extremes of heat and cold, worsening symptoms with stress), and immune manifestations (such as tender lymph nodes, recurrent sore throat or flu-like symptoms, general malaise (flu-like feelings of being ill and feverish)

Glutathione supplements are available in various forms, including oral capsules, sublingual formulations, intravenous injections, and topical creams

Most people do not experience symptoms from high B12 itself

Interestingly, IPA software predicted an inhibition of oxidative phosphorylation in metformin treated SW837 cells, supporting the demonstrated metformin-induced inhibition of OCR using Seahorse live-cell metabolic profiling ( Figure 1 )