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Wound healing acceleration: The peptide promotes angiogenesis through VEGF upregulation, enhancing nutrient delivery and accelerating dermal wound closure in multiple animal and human tissue models

In mouse nucleus accumbens (NAc), Cdc42 was activated by methamphetamine (METH) and viral expression of dominant negative and constitutively active Cdc42 impaired and enhanced METH-induced CPP memory, respectively (Tu et al., 2019)

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Enhanced blood vessel formation could theoretically support tumor growth and spread

Furthermore, owing to the heterogeneity and diversity of tumor cells themselves, the role of IGFs is not necessarily only as a tumor suppressor, so the development of related inhibitors must fully consider the impact on the tumor and its surrounding environment