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Our findings provide evidence that traditional continuous change from baseline analyses using uncensored data might underestimate disease progression and potentially mask the effects of novel treatments aimed at slowing disease progression

The price gap reflects differences in manufacturing and distribution, not a difference in the medication itself

Each sells clinical or quasi-clinical services directly to consumers, yet their growth playbooks resemble sneaker drops or skincare launches more than scientific enterprises

2APB: 2-aminoethoxydipenyl-borate APAP: acetaminophen DAMPs: damage-associated molecular patterns DMSO: dimethyl sulfoxide GSH: glutathione LDH: lactate dehydrogenase LPO: lipid peroxidation MPTP: mitochondrial membrane permeability transition pore NAC: N -acetylcysteine NK: natural killer NNT: nicotinamide nucleotide transhydrogenase P-JNK: phosphorylation of c-jun N-terminal kinase PUFAs: polyunsaturated fatty acids ROS: reactive oxygen species SEC: sinusoidal endothelial cell HJ: Conceptualization, Writingoriginal draft, Writingreview & editing