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The CTG assay showed that RNK06138 reduces the viability of MOLP-8 (IC 50 = 98.39 nM), MDA-MB-231 (IC 50 = 190 nM), Huh-7 (IC 50 = 110.15 nM), A427 (IC 50 = 83.04 nM), JHH-7 (IC 50 = 142.44 nM), and A375 cells (IC 50 = 60.23 nM) (Fig

Laboratory tests of liver function are indicated if liver disease is suggested by the history and physical examination

In human SH-SY5Y neuroblastoma cells, a well-established model for studying neuronal behavior, Epitalon significantly increased the secretion of soluble amyloid precursor protein (sAPP) by ~20%

Murali CN, Barber JR, McCarter R, Zhang A, Gallant N, Simpson K, et al

Purity and cell death was assessed by flow cytometry on a BD LSRFortessa and cells were pooled to a total of 1.5 10 6 cells per sample, washed with HBSS and resuspended in methanol