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although its chemical activity is similar to the original drug, MTX-PG 2-6 is preferentially kept in the intracellular environment [whereas non-glutamylated MTX is quickly exported by ABC transporters ( MTX primarily acts by inhibiting dihydrofolate reductase (DHFR), which catalyzes the sequential conversion of folic acid to dihydrofolate (DHF) and tetrahydrofolate (THF)

Zhang M, Wang W, Liu K et al (2023) Astragaloside IV protects against lung injury and pulmonary fibrosis in COPD by targeting GTP-GDP domain of RAS and downregulating the RAS/RAF/FoxO signaling pathway

404 It has been reported that zinc can inhibit the proliferation of colon cancer cells by arresting the cell cycle in the G2/M phase and disrupting the microtubule stability of cell-cell communication

doi: 10.1002/ptr.7176 107 MiY.ZhangW.TianH.LiR.HuangS.LiX.et al