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Practical takeaway: FOXO4-DRI's senolytic mechanism is well-established in cell culture and animal models

Management typically involves estrogen monitoring through blood tests and, when necessary, aromatase inhibitors or selective estrogen receptor modulators

Avoid contamination during handling and maintain sterile technique throughout laboratory use

Subsequently, 0.4 mL of a PI staining/lysis solution (0.5% NP-40, 0.5 mM ethylenediaminetetraacetic acid [EDTA]) and 50 L of RNase A (10 mg/mL in TrisEDTA buffer, pH 8.0) solution were added

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